Article
Whole Exome Sequencing in Psoriasis Patients Contributes to Studies of Acitretin Treatment Difference.
International journal of molecular sciences - 29 Jan 2017
Zhou Xingchen, He Yijing, Kuang Yehong, Li Jie, Zhang Jianglin, Chen Mingliang, Chen Wangqing, Su Juan, Zhao Shuang, Liu Panpan, Chen Menglin, Shen Minxue, Chen Xiaoping, Zhu Wu, Chen Xiang
Abstract excerpt
Psoriasis vulgaris is an immune-mediated inflammatory skin disease. Although acitretin is a widely used synthetic retinoid for moderate to severe psoriasis, little is known about patients' genetics in response to this drug. In this study, 179 patients were enrolled in either the discovery set (13 patients) or replication set (166 patients). The discovery set was sequenced by whole exome sequencing and sequential...
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