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Article

Rare germline alterations in cancer-related genes associated with the risk of multiple primary tumor development.

Journal of molecular medicine (Berlin, Germany) - 1 May 2017

Villacis Rolando A R, Basso Tatiane R, Canto Luisa M, Pinheiro Maísa, Santiago Karina M, Giacomazzi Juliana, de Paula Cláudia A A, Carraro Dirce M, Ashton-Prolla Patrícia, Achatz Maria I, Rogatto Silvia R

Abstract excerpt

Multiple primary tumors (MPT) have been described in carriers of inherited cancer predisposition genes. However, the genetic etiology of a large proportion of MPT cases remains unclear. We reviewed 267 patients with hereditary cancer predisposition syndromes (HCPS) that underwent genetic counseling and selected 22 patients with MPT to perform genomic analysis (CytoScan HD Array, Affymetrix) aiming to identify new...

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cell Adhesion Molecule

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Share to Germ-Line Mutation

Share to Loss of Heterozygosity

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Source

Identifiers

PMID: 28093616
DOI: 10.1007/s00109-017-1507-7

Genes

EPCAM
MSH2
ABCC1
MYH11
NDE1
PIWIL2
ULK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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