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Article

How stra(i)nge are your controls? A comparative analysis of metabolic phenotypes in commonly used C57BL/6 substrains.

PloS one - 1 Jan 2023

Sil Annesha, Souza Matos Marina, Delibegovic Mirela, Platt Bettina

Abstract excerpt

In recent years, insufficiently characterised controls have been a contributing factor to irreproducibility in biomedical research including neuroscience and metabolism. There is now a growing awareness of phenotypic differences between the C57BL/6 substrains which are commonly used as control animals. We here investigated baseline metabolic characteristics such as glucose regulation, fasted serum insulin levels...

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PMID: 37531359
DOI: 10.1371/journal.pone.0289472
PMCID: PMC10395817

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