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Article

Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants.

PLoS genetics - 1 Nov 2019

Snedeker John, Gibbons William J, Paulding David F, Abdelhamed Zakia, Prows Daniel R, Stottmann Rolf W

Abstract excerpt

The primary cilium is a signaling center critical for proper embryonic development. Previous studies have demonstrated that mice lacking Ttc21b have impaired retrograde trafficking within the cilium and multiple organogenesis phenotypes, including microcephaly. Interestingly, the severity of the microcephaly in Ttc21baln/aln homozygous null mutants is considerably affected by the genetic background and mutants on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31730647
DOI: 10.1371/journal.pgen.1008467
PMCID: PMC6881074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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