Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and phenotypic analysis of Tcm, a mutation affecting early eye development.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 2005

Wang Ken S, Zahn Lauren E, Favor Jack, Huang Kristen M, Stambolian Dwight

Abstract excerpt

Tcm (total cataract with microphthalmia) is an autosomal dominant mouse eye mutation. Heterozygous Tcm/+ mice are born with several eye malformations including microphthalmia, retinal and iris dysplasia, total lens cataract, and ventral coloboma. The Tcm mutation was previously mapped to a 26-Mb region on Chr 4 between D4Mit235 and D4Mit106. In this study, we characterize the Tcm/ Tcm homozygous mutant and find...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Cataract
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Mice, Inbred C3H

Share to Microphthalmos

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 16104381
DOI: 10.1007/s00335-004-2444-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and phenotypic analysis of Tcm, a mutation affecting early eye development.PMID 16104381Read ↗

Genome-wide screening reveals the genetic basis of mammalian embryonic eye development.Semantic proximity Read ↗

Genetic spectrum of congenital cataract with optional ocular and multisystem abnormalitiesSemantic proximity Read ↗

Identification of genes required for eye development by high-throughput screening of mouse knockoutsSemantic proximity Read ↗

Mutations in c12orf57 cause a syndromic form of colobomatous microphthalmia.Semantic proximity Read ↗

Whole-exome sequencing prioritizes candidate genes for hereditary cataract in the Emory mouse mutant.Semantic proximity Read ↗

Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development.Semantic proximity Read ↗

Genetic analyses enabled by the fourth chromosome resource project reveal unexpected mutant phenotypes and suggest new disease models.Semantic proximity Read ↗

Characterization of a spontaneous microphthalmia-like mutant mouse with isolated ocular defects.Semantic proximity Read ↗

Quantitative trait loci affecting phenotypic variation in the vacuolated lens mouse mutant, a multigenic mouse model of neural tube defects.Semantic proximity Read ↗

A mouse model of brittle cornea syndrome caused by mutation in Zfp469.Semantic proximity Read ↗

Homozygous null mutation in ODZ3 causes microphthalmia in humans.Semantic proximity Read ↗

Mouse models for microphthalmia, anophthalmia and cataractsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.