Article
[Evaluation of BRAF V600E Mutations in High-Level Microsatellite Instability(MSI-H)Colon Cancer - Comparison Between Genetic Testing and Immunohistochemical Staining].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Nov 2016
Sakimoto Takehiko, Chika Noriyasu, Suzuki Okihide, Ishibashi Keiichiro, Tachikawa Tetsuhiko, Akagi Kiwamu, Eguchi Hidetaka, Okazaki Yasushi, Ishida Hideyuki
Abstract excerpt
BRAF V600E mutation plays an important role in the serrated neoplasia pathway of colorectal tumorigenesis and is a negative predictive factor for chemotherapy response as well as a prognostic factor in patients with colorectal cancer. To evaluate BRAF V600E mutations, a conventional polymerase chain reaction(PCR)is performed but recently immunohistochemistry (IHC)with a BRAF antibody has been used. Although...
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