Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[A Case of Colon Cancer with Familial Adenomatous Polyposis Showing MSI-H and Deletion of MSH2/MSH6 Protein].

Gan to kagaku ryoho. Cancer & chemotherapy - 1 Nov 2015

Suzuki Okihide, Chika Noriyasu, Fukuchi Minoru, Kumamoto Kensuke, Kumagai Youichi, Ishibashi Keiichiro, Eguchi Hidetaka, Mochiki Erito, Akagi Kiwamu, Ishida Hideyuki

Abstract excerpt

A 31-year-old woman with familial adenomatous polyposis (FAP) was diagnosed with colon cancer. Genetic testing showed a germ cell line mutation of APC (a frame-shift mutation). Moreover, deletion of MSH2/MSH6 protein and high microsatellite instability (MSI-H) was detected. Therefore, Lynch syndrome (LS) associated with FAP was suspected. Additional analysis showed no pathogenic mutation of MSH2 and no change in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Fatal Outcome

Share to Gene Deletion

Share to Microsatellite Instability

Share to MutS Homolog 2 Protein

Share to Pedigree

Source

Identifiers

PMID: 26805313

Genes

MSH2
APC
FAP
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[A Case of Colon Cancer with Familial Adenomatous Polyposis Showing MSI-H and Deletion of MSH2/MSH6 Protein].PMID 26805313Read ↗

[Concurrent APC and MLH1mutations identified in a family affected with familial adenomatous polyposis].Semantic proximity Read ↗

[Molecular and genetic studies for hereditary colon cancer in two patients and their families].Semantic proximity Read ↗

Attenuated adenomatous polyposis with MSH6 variation: two case reportsSemantic proximity Read ↗

[Hereditary non-polyposis colorectal cancer. Report of four siblings].Semantic proximity Read ↗

Somatic mosaicism and double somatic hits can lead to MSI colorectal tumors.Semantic proximity Read ↗

A novel MSH2 mutation in a Chinese family with hereditary non-polyposis colorectal cancer.Semantic proximity Read ↗

[Hereditary colorectal cancer: Molecular analysis of APC and MLH1 genes].Semantic proximity Read ↗

[Mutation analysis on MSH2 and MLH1 genes in patients of colorectal cancer at early age].Semantic proximity Read ↗

[A case of lynch syndrome treated laparoscopically for multiple colon cancers].Semantic proximity Read ↗

[Homozygous germline mutation in MUTYH gene in familial adenomatous polyposis].Semantic proximity Read ↗

[Mutation screening of MLH1 and MSH2 genes in two Chinese families with hereditary nonpolyposis colorectal cancer].Semantic proximity Read ↗

[A colo-colic invagination on the basis of MutYH-associated polyposis in a boy aged 14].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.