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miRNA-Based Therapeutics in the Era of Immune-Checkpoint Inhibitors

26 Jan 2021

Abstract excerpt

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to complementary target regions on gene transcripts. Thus, miRNAs fine-tune gene expression profiles in a cell-type-specific manner and thereby regulate important cellular functions, such as cell growth, proliferation and cell death. MiRNAs are frequently dysregulated in cancer cells by several mechanisms, which significantly...

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PMID: 33530393
DOI: 10.3390/ph14020089

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