Article
Dopamine receptor and Gα(olf) expression in DYT1 dystonia mouse models during postnatal development.
PloS one - 1 Jan 2015
Zhang Lin, McCarthy Deirdre M, Sharma Nutan, Bhide Pradeep G
Abstract excerpt
BACKGROUND: DYT1 dystonia is a heritable, early-onset generalized movement disorder caused by a GAG deletion (ΔGAG) in the DYT1 gene. Neuroimaging studies and studies using mouse models suggest that DYT1 dystonia is associated with dopamine imbalance. However, whether dopamine imbalance is key to DYT1 or other forms of dystonia continues to be debated. METHODOLOGY/PRINCIPAL FINDINGS: We used Dyt1 knock out (Dyt1...
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