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Article

Motor deficits and hyperactivity in Dyt1 knockdown mice.

Neuroscience research - 1 Dec 2006

Dang Mai T, Yokoi Fumiaki, Pence Morgan A, Li Yuqing

Abstract excerpt

The DYT1 gene containing a trinucleotide deletion (DeltaGAG) is linked to early-onset dystonia, a neurological movement disorder of involuntary muscle contractions. To understand DYT1's contribution to dystonia, we produced and analyzed Dyt1 knockdown (KD) mice that expressed a reduced level of torsinA protein encoded by Dyt1. Knockdown mice exhibited deficits in motor control and a decreased trend in dopamine...

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Identifiers

PMID: 17046090
DOI: 10.1016/j.neures.2006.09.005
PMCID: PMC1794321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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