Article
Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents.
Nature communications - 6 Nov 2014
Gerdes Jantje M, Christou-Savina Sonia, Xiong Yan, Moede Tilo, Moruzzi Noah, Karlsson-Edlund Patrick, Leibiger Barbara, Leibiger Ingo B, Östenson Claes-Göran, Beales Philip L, Berggren Per-Olof
Abstract excerpt
Type 2 diabetes mellitus is affecting more than 382 million people worldwide. Although much progress has been made, a comprehensive understanding of the underlying disease mechanism is still lacking. Here we report a role for the β-cell primary cilium in type 2 diabetes susceptibility. We find impaired glucose handling in young Bbs4(-/-) mice before the onset of obesity. Basal body/ciliary perturbation in murine...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.