Article
BRAFK601E Mutation in a Follicular Thyroid Adenoma: A Case Report.
International journal of surgical pathology - 1 Jun 2017
Macerola Elisabetta, Torregrossa Liborio, Ugolini Clara, Bakkar Sohail, Vitti Paolo, Fadda Guido, Basolo Fulvio
Abstract excerpt
BRAF mutations represent the most common genetic alteration in papillary thyroid carcinoma (PTC). The p.V600E mutation is specific for the classic and tall-cell variants of PTC and has been associated with a more aggressive biologic behavior. On the other hand, the p.K601E mutation is peculiar to the follicular variant of PTC, and seems to be a favorable prognostic indicator. A 12-year-old boy presented with a...
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