Article
Thyroid hormone transporters in the brain.
Reviews in the neurosciences - 1 Jan 2010
Braun Doreen, Wirth Eva K, Schweizer Ulrich
Abstract excerpt
Thyroid hormones are essential for brain development. The active thyroid hormone, T3, binds to several products of two genes, the nuclear thyroid hormone receptors alpha and beta, and thus regulates gene expression. Mutations in a thyroid hormone transmembrane transport protein, monocarboxylate transporter 8 (MCT8), underlie one of the first described X-linked mental retardation syndromes, the...
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