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Article

Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8.

The Journal of biological chemistry - 3 Sept 2010

Kinne Anita, Kleinau Gunnar, Hoefig Carolin S, Grüters Annette, Köhrle Josef, Krause Gerd, Schweizer Ulrich

Abstract excerpt

Monocarboxylate transporter 8 (MCT8, SLC16A2) is a thyroid hormone (TH) transmembrane transport protein mutated in Allan-Herndon-Dudley syndrome, a severe X-linked psychomotor retardation. The neurological and endocrine phenotypes of patients deficient in MCT8 function underscore the physiological significance of carrier-mediated TH transmembrane transport. MCT8 belongs to the major facilitator superfamily of 12...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20628049
DOI: 10.1074/jbc.M110.129577
PMCID: PMC2934670

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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