Article
Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBA/CaJ Mice.
Neural plasticity - 1 Jan 2016
Fu Xiaolong, Zhang Linqing, Jin Yecheng, Sun Xiaoyang, Zhang Aizhen, Wen Zongzhuang, Zhou Yichen, Xia Ming, Gao Jiangang
Abstract excerpt
MYH14 is a member of the myosin family, which has been implicated in many motile processes such as ion-channel gating, organelle translocation, and the cytoskeleton rearrangement. Mutations in MYH14 lead to a DFNA4-type hearing impairment. Further evidence also shows that MYH14 is a candidate noise-induced hearing loss (NIHL) susceptible gene. However, the specific roles of MYH14 in auditory function and NIHL are...
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