Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IFN-γ regulates human dental pulp stem cells behavior via NF-κB and MAPK signaling.

Scientific reports - 18 Jan 2017

He Xinyao, Jiang Wenkai, Luo Zhirong, Qu Tiejun, Wang Zhihua, Liu Ningning, Zhang Yaqing, Cooper Paul R, He Wenxi

Abstract excerpt

During caries, dental pulp expresses a range of pro-inflammatory cytokines in response to the infectious challenge. Interferon gamma (IFN-γ) is a dimerized soluble cytokine, which is critical for immune responses. Previous study has demonstrated that IFN-γ at relative high concentration (100 ng/mL) treatment improved the impaired dentinogenic and immunosuppressive regulatory functions of disease-derived dental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to Dental Pulp
Share to Immunophenotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-gamma

Share to Mitogen-Activated Protein Kinases

Share to NF-kappa B

Share to Osteogenesis

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 28098169
DOI: 10.1038/srep40681
PMCID: PMC5241669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IFN-γ regulates human dental pulp stem cells behavior via NF-κB and MAPK signaling.PMID 28098169Read ↗

Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells.Semantic proximity Read ↗

Effects of Porphyromonas gingivalis lipopolysaccharide on the behavior of human dental pulp stem cells in vitro and their inflammation-related transcriptomics profileSemantic proximity Read ↗

Evaluating the effect of LPS from periodontal pathogenic bacteria on the expression of senescence‐related genes in human dental pulp stem cellsSemantic proximity Read ↗

ATF3 triggers M2 macrophage polarization to protect against pulp inflammation through WNT4 regulationSemantic proximity Read ↗

Effects of sclerostin on lipopolysaccharide-induced inflammatory phenotype in human odontoblasts and dental pulp cells.Semantic proximity Read ↗

Potentiality and Inflammatory Marker Expression Are Maintained in Dental Pulp Cell Cultures from Carious TeethSemantic proximity Read ↗

A short-term treatment with tumor necrosis factor-alpha enhances stem cell phenotype of human dental pulp cells.Semantic proximity Read ↗

The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs.Semantic proximity Read ↗

Effects of miR-629-5p on odontoblast differentiation and target gene TEAD4 expression of dental pulp stem cellsSemantic proximity Read ↗

Dysregulation of lncRNA GATA3-AS1 is Involved in the Pathogenesis of Pulpitis by the Regulation of miR-17-3pSemantic proximity Read ↗

The existence of CD11c+ sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties.Semantic proximity Read ↗

B2M or CIITA knockdown decreased the alloimmune response of dental pulp stem cells: an in vitro studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.