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Article

The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs.

The international journal of biochemistry & cell biology - 1 Feb 2016

Đorđević Ivana Okić, Kukolj Tamara, Krstić Jelena, Trivanović Drenka, Obradović Hristina, Santibañez Juan F, Mojsilović Slavko, Ilić Vesna, Bugarski Diana, Jauković Aleksandra

Abstract excerpt

Periodontal disease (PD), a degenerative bacterially induced disease of periodontium, can lead to bone resorption and teeth loss. Development of PD includes a strong inflammatory reaction, which involves multiple immune cells and their secreting factors including interleukin-17 (IL-17), which is not only an important modulator of immune and hematopoietic responses but also affects bone metabolism. In the present...

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PMID: 26718973
DOI: 10.1016/j.biocel.2015.12.007

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