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Article

Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia.

Leukemia - 1 Jun 2017

Karol S E, Larsen E, Cheng C, Cao X, Yang W, Ramsey L B, Fernandez C A, McCorkle J R, Paugh S W, Autry R J, Lopez-Lopez E, Diouf B, Jeha S, Pui C-H, Raetz E A, Winick N J, Carroll W L, Hunger S P, Loh M L, Devidas M, Evans W E, Yang J J, Relling M V

Abstract excerpt

The causes of individual relapses in children with acute lymphoblastic leukemia (ALL) remain incompletely understood. We evaluated the contribution of germline genetic factors to relapse in 2225 children treated on Children's Oncology Group trial AALL0232. We identified 302 germline single-nucleotide polymorphisms (SNPs) associated with relapse after adjusting for treatment and ancestry and 715 additional SNPs...

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Source

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Identifiers

PMID: 28096535
DOI: 10.1038/leu.2017.24
PMCID: PMC5462853

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