Article
Genetic Polymorphisms of rs3077 and rs9277535 in HLA-DP associated with Systemic lupus erythematosus in a Chinese population.
Scientific reports - 17 Jan 2017
Zhang Junlong, Zhan Wenli, Yang Bin, Tian Anning, Chen Lin, Liao Yun, Wu Yongkang, Cai Bei, Wang Lanlan
Abstract excerpt
Although the SLE risk gene loci of HLA-DR and HLA-DQ within the major histocompatibility complex (MHC) region has been gradually revealed by recent Genome-Wide Association studies (GWAS), the association of HLA-DP polymorphisms with SLE was minimally reported. Considering that the variants in rs3077 and rs9277535 in the HLA-DP region could influence the immune response by affecting antigen presentation of HLA...
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