Article
Genetic polymorphism of rs9277535 in HLA-DP associated with rheumatoid arthritis and anti-CCP production in a Chinese population.
Clinical rheumatology - 1 Jul 2018
Huang Zhuochun, Niu Qian, Yang Bin, Zhang Junlong, Yang Min, Xu Huan, Cai Bei, Hu Jing, Wu Yongkang, Wang Lanlan
Abstract excerpt
HLA-II molecules are critical in triggering human immune response, especially in activating CD4+ T cells. HLA-DP, belonging to HLA-II molecules, draws increasing attention for its role in presentation of viral antigen and autoantigen to T cells. Researches reported single nucleotide polymorphism (SNP) of HLA-DP associated with HBV infection and autoimmune diseases such as SLE. However, little is known about the...
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