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Article

Detection of Rare Mutations by Routine Analysis of KRAS, NRAS, and BRAF Oncogenes.

Bulletin of experimental biology and medicine - 1 Jan 2017

Mikhailenko D S, Efremov G D, Safronova N Yu, Strelnikov V V, Alekseev B Ya

Abstract excerpt

Molecular genetic analysis of KRAS, NRAS, and BRAF genes was carried out in order to develop an optimal algorithm for detection of minor mutations. We analyzed 35 melanoma and 33 colorectal cancer specimens. Frequent G12D/V/A/C/S mutations were detected in KRAS. The most frequent BRAF mutation in melanoma was V600E, the percentage of rare mutations is significant for DNA diagnosis (24%). Identification of rare...

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Identifiers

PMID: 28091917
DOI: 10.1007/s10517-017-3619-z

Genes

BRAF
KRAS
NRAS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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