Multicenter Evaluation of the Idylla NRAS-BRAF Mutation Test in Metastatic Colorectal Cancer.

doi:10.1016/j.jmoldx.2018.05.008

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Multicenter Evaluation of the Idylla NRAS-BRAF Mutation Test in Metastatic Colorectal Cancer.

The Journal of molecular diagnostics : JMD - 1 Sept 2018

Prieto-Potin Iván, Montagut Clara, Bellosillo Beatriz, Evans Matthew, Smith Matthew, Melchior Linea, Reiltin Werner, Bennett Michael, Pennati Veronica, Castiglione Francesca, Bürrig Karl-Friedrich, Cooper Ulrike, Dockhorn-Dworniczak Barbara, Rossenbach Christiana, Luna-Aguirre Claudia M, Barrera-Saldaña Hugo A, Machado José C, Costa José L, Yacobi Rinat, Tabibian-Keissar Hilla, Buglioni Simonetta, Ronchetti Livia, Douglas-Berger Lotte, Dubbink Hendrikus J, Alorini Mohammed, Sabourin Jean-Christophe, Rojo Federico

Abstract excerpt

Treatment of colorectal cancer (CRC) with monoclonal antibodies against epidermal growth factor receptor requires the assessment of the mutational status of exons 2, 3, and 4 of the NRAS and KRAS oncogenes. Moreover, the mutational status of exon 15 of the BRAF oncogene is a marker of poor prognosis in CRC. The Idylla NRAS-BRAF Mutation Test is a reliable, simple (<2 minutes hands-on time), and quick (<2 hours...

Topics

Colorectal Neoplasms
DNA Mutational Analysis
GTP Phosphohydrolases
Humans
Membrane Proteins
Mutation
Proto-Oncogene Proteins B-raf

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reference Standards

Reproducibility of Results

Source

Open in PubMed

Identifiers

PMID: 29959022
DOI: 10.1016/j.jmoldx.2018.05.008

Genes

BRAF
NRAS
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.