Article
A powerful statistical framework for generalization testing in GWAS, with application to the HCHS/SOL.
Genetic epidemiology - 1 Apr 2017
Sofer Tamar, Heller Ruth, Bogomolov Marina, Avery Christy L, Graff Mariaelisa, North Kari E, Reiner Alex P, Thornton Timothy A, Rice Kenneth, Benjamini Yoav, Laurie Cathy C, Kerr Kathleen F
Abstract excerpt
In genome-wide association studies (GWAS), "generalization" is the replication of genotype-phenotype association in a population with different ancestry than the population in which it was first identified. Current practices for declaring generalizations rely on testing associations while controlling the family-wise error rate (FWER) in the discovery study, then separately controlling error measures in the...
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