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Article

Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 (CES1) Variants.

Clinical and translational science - 1 Dec 2016

Lyauk Y K, Stage C, Bergmann T K, Ferrero-Milliani L, Bjerre D, Thomsen R, Dalhoff K P, Rasmussen H B, Jürgens G

Abstract excerpt

The aim of this study was to identify demographic and genetic factors that significantly affect methylphenidate (MPH) pharmacokinetics (PK), and may help explain interindividual variability and further increase the safety of MPH. d-MPH plasma concentrations, demographic covariates, and carboxylesterase 1 (CES1) genotypes were gathered from 122 healthy adults and analyzed using nonlinear mixed effects modeling....

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Identifiers

PMID: 27754602
DOI: 10.1111/cts.12423
PMCID: PMC5351003

Genes

CES1

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