Article
Fitness decline in spontaneous mutation accumulation lines of Caenorhabditis elegans with varying effective population sizes.
Evolution; international journal of organic evolution - 1 Jan 2015
Katju Vaishali, Packard Lucille B, Bu Lijing, Keightley Peter D, Bergthorsson Ulfar
Abstract excerpt
The rate and fitness effects of new mutations have been investigated by mutation accumulation (MA) experiments in which organisms are maintained at a constant minimal population size to facilitate the accumulation of mutations with minimal efficacy of selection. We evolved 35 MA lines of Caenorhabditis elegans in parallel for 409 generations at three population sizes (N = 1, 10, and 100), representing the first...
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