Article
No Evidence for Association of β-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS.
Annals of human genetics - 1 Jan 2017
Abujaber Razan, Shea Patrick R, McLaren Paul J, Lakhi Shabir, Gilmour Jill, Allen Susan, Fellay Jacques, Hollox Edward J
Abstract excerpt
Common single-nucleotide variation in the host accounts for 25% of the variability in the plasma levels of HIV during the clinical latency stage (viral load set point). However, the role of rare variants and copy number variants remains relatively unexplored. Previous work has suggested copy number variation of a cluster of β-defensin genes affects HIV load in treatment-naïve sub-Saharan Africans and rate of...
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