Article
A bioinformatics tool for ensuring the backwards compatibility of Legionella pneumophila typing in the genomic era.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 May 2017
Gordon M, Yakunin E, Valinsky L, Chalifa-Caspi V, Moran-Gilad J
Abstract excerpt
OBJECTIVES: Whole genome sequencing (WGS) has revolutionized the subtyping of Legionella pneumophila but calling the traditional sequence-based type from genomic data is hampered by multiple copies of the mompS locus. We propose a novel bioinformatics solution for rectifying that limitation, ensuring the feasibility of WGS for cluster investigation. METHODS: We designed a novel approach based on the alignment of...
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