Article
Design and application of a core genome multilocus sequence typing scheme for investigation of Legionnaires' disease incidents.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 16 Jul 2015
Moran-Gilad J, Prior K, Yakunin E, Harrison T G, Underwood A, Lazarovitch T, Valinsky L, Luck C, Krux F, Agmon V, Grotto I, Harmsen D
Abstract excerpt
Sequence-based typing (SBT) for Legionella pneumophila (Lp) has dramatically improved Legionnaires’ disease (LD) cluster investigation. Microbial whole genome sequencing (WGS) is a promising modality for investigation but sequence analysis methods are neither standardised, nor agreed. We sought to develop a WGS-based typing scheme for Lp using de novo assembly and a genome-wide gene-by-gene approach (core genome...
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