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Article

Dynamic Interconversions of HCV Helicase Binding Modes on the Nucleic Acid Substrate.

ACS infectious diseases - 13 Jan 2017

Ablenas Christopher J, Liu Hsiao-Wei, Shkriabai Nikoloz, Kvaratskhelia Mamuka, Cosa Gonzalo, Götte Matthias

Abstract excerpt

The dynamics involved in the interaction between hepatitis C virus nonstructural protein 3 (NS3) C-terminal helicase and its nucleic acid substrate have been the subject of interest for some time given the key role of this enzyme in viral replication. Here, we employed fluorescence-based techniques and focused on events that precede the unwinding process. Both ensemble Förster resonance energy transfer (FRET) and...

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PMID: 28081608
DOI: 10.1021/acsinfecdis.6b00177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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