Article
Mimiviruses and the Human Interferon System: Viral Evasion of Classical Antiviral Activities, But Inhibition By a Novel Interferon-β Regulated Immunomodulatory Pathway.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Jan 2017
Almeida Gabriel Magno de Freitas, Silva Lorena C Ferreira, Colson Philippe, Abrahao Jonatas Santos
Abstract excerpt
In this review we discuss the role of mimiviruses as potential human pathogens focusing on clinical and evolutionary evidence. We also propose a novel antiviral immunomodulatory pathway controlled by interferon-β (IFN-β) and mediated by immune-responsive gene 1 (IRG1) and itaconic acid, its product. Acanthamoeba polyphaga Mimivirus (APMV) was isolated from amoebae in a hospital while investigating a pneumonia...
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