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Article

Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer's disease: a retrospective cohort study.

The Lancet. Neurology - 1 Mar 2011

Acosta-Baena Natalia, Sepulveda-Falla Diego, Lopera-Gómez Carlos Mario, Jaramillo-Elorza Mario César, Moreno Sonia, Aguirre-Acevedo Daniel Camilo, Saldarriaga Amanda, Lopera Francisco

Abstract excerpt

BACKGROUND: Mild cognitive impairment (MCI) and pre-MCI have been proposed as stages preceding Alzheimer's disease (AD) dementia. We assessed descendants of individuals with a mutation in presenilin 1 (PSEN1) that causes familial AD, with the aim of identifying distinct stages of clinical progression to AD dementia. METHODS: We retrospectively studied a cohort of descendants of carriers of the PSEN1 E280A...

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PMID: 21296022
DOI: 10.1016/S1474-4422(10)70323-9

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PSEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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