Article
In silico analysis of the deleterious nsSNPs (missense) in the homeobox domain of human HOXB13 gene responsible for hereditary prostate cancer.
Chemical biology & drug design - 1 Aug 2017
Chandrasekaran Gopalakrishnan, Hwang Eu Chang, Kang Taek Won, Kwon Dong Deuk, Park Kwangsung, Lee Je-Jung, Lakshmanan Vinoth-Kumar
Abstract excerpt
The human HOXB13 gene encodes a transcription factor containing a DNA-binding homeobox domain and a HoxA13 N-terminal domain. SNP is considered to be the primary genetic cause for hereditary prostate cancer (PCa). The study of functional nsSNPs would give an insight into the exact cause underlying the onset of hereditary PCa and possible methodologies for the cure or early management of the disease. Several in...
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