Article
Mutation in an Unannotated Protein Confers Carbapenem Resistance in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy - 1 Mar 2017
Kumar Pankaj, Kaushik Amit, Bell Drew T, Chauhan Varsha, Xia Fangfang, Stevens Rick L, Lamichhane Gyanu
Abstract excerpt
β-Lactams are the most widely used antibacterials. Among β-lactams, carbapenems are considered the last line of defense against recalcitrant infections. As recent developments have prompted consideration of carbapenems for treatment of drug-resistant tuberculosis, it is only a matter of time before Mycobacterium tuberculosis strains resistant to these drugs will emerge. In the present study, we investigated the...
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