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Article

Study of pyrazinamidase structural changes in pyrazinamide resistant and susceptible isolates of Mycobacterium tuberculosis.

Tuberkuloz ve toraks - 1 Jan 2013

Ahmady Azam, Poolad Toktam, Rafee Poorya, Tousheh Mojtaba, Kahbazi Manijeh, Arjomandzadegan Mohammad

Abstract excerpt

INTRODUCTION: Pyrazinamide is one of the first line four drugs for treatment of tuberculosis. It was proved that mutations in two nucleotides of 359 and 374 pnc genes are highly associated with resistance to pyrazinamide. MATERIALS AND METHODS: In this study, mutations in these two codones in 30 clinical isolates of Mycobacterium tuberculosis were detected by means of sequencing. Protein structures encoded by...

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Identifiers

PMID: 23875588
DOI: 10.5578/tt.3888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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