Correlation between penicillin-binding protein 2 mutations and carbapenem resistance in Escherichia coli.

Abstract excerpt

It is well known that carbapenem-resistant mutations in penicillin-binding proteins (PBPs) are not observed in most Gram-negative bacteria under either clinical or experimental conditions. To understand the mechanisms involved in carbapenem resistance, this study constructed a mutS- and tolC-deficient Escherichia coli strain, which was expected to have elevated mutation frequencies and to lack drug efflux. Using...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Carbapenems
• Share to DNA Repair
• Share to Drug Resistance, Bacterial