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Article

EXT gene family member rib-2 is essential for embryonic development and heparan sulfate biosynthesis in Caenorhabditis elegans.

Biochemical and biophysical research communications - 7 Feb 2003

Morio Hidenori, Honda Yoko, Toyoda Hidenao, Nakajima Mitsunari, Kurosawa Hisashi, Shirasawa Takuji

Abstract excerpt

EXT gene family members including EXT1, EXT2, and EXTL2 are glycosyltransferases required for heparan sulfate biosynthesis. To examine the biological functions of rib-2, a member of the Caenorhabditis elegans EXT gene family, we generated a mutant worm lacking the rib-2 gene using the UV-TMP meth...

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Source

Identifiers

PMID: 12565862
DOI: 10.1016/s0006-291x(02)03031-0

Genes

EXT1
EXT2
EXTL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12565862-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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EXT gene family member rib-2 is essential for embryonic development and heparan sulfate biosynthesis in Caenorhabditis elegans.PMID 12565862Read ↗

Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans.Semantic proximity Read ↗

Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans.Semantic proximity Read ↗

Transgenic expression of the EXT2 gene in developing chondrocytes enhances the synthesis of heparan sulfate and bone formation in mice.Semantic proximity Read ↗

Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice.Semantic proximity Read ↗

A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses.Semantic proximity Read ↗

HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development.Semantic proximity Read ↗

Mice deficient in Ext2 lack heparan sulfate and develop exostosesSemantic proximity Read ↗

Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains.Semantic proximity Read ↗

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Caenorhabditis elegans syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva.Semantic proximity Read ↗

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