Article
Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation.
Molecular cell - 19 Jan 2017
Ma Li, Huang Chao, Wang Xiong-Jun, Xin Dazhuan Eric, Wang Li-Shun, Zou Quanli C, Zhang Ya-Nan S, Tan Min-Dian, Wang Yu-Mei, Zhao Ting C, Chatterjee Devasis, Altura Rachel A, Wang Chuangui, Xu Yan S, Yang Jing-Hua, Fan Yong-Sheng, Han Bao-Hui, Si Jianmin, Zhang Xiaoren, Cheng Jinke, Chang Zhijie, Chin Y Eugene
Abstract excerpt
In mammalian cells, histone deacetylase (HDAC) and Sirtuin (SIRT) are two families responsible for removing acetyl groups from acetylated proteins. Here, we describe protein deacetylation coupled with deacetylimination as a function of lysyl oxidase (LOX) family members. LOX-like 3 (Loxl3) associates with Stat3 in the nucleus to deacetylate and deacetyliminate Stat3 on multiple acetyl-lysine sites. Surprisingly,...
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