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Article

Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma.

PloS one - 1 Jan 2015

Simpson Haley M, Khan Rashid Z, Song Chang, Sharma Deva, Sadashivaiah Kavitha, Furusawa Aki, Liu Xinyue, Nagaraj Sushma, Sengamalay Naomi, Sadzewicz Lisa, Tallon Luke J, Chen Qing C, Livak Ferenc, Rapoport Aaron P, Kimball Amy, Banerjee Arnob

Abstract excerpt

Peripheral T cell lymphoma (PTCL) is a heterogeneous malignancy with poor response to current therapeutic strategies and incompletely characterized genetics. We conducted whole exome sequencing of matched PTCL and non-malignant samples from 12 patients, spanning 8 subtypes, to identify potential oncogenic mutations in PTCL. Analysis of the mutations identified using computational algorithms, CHASM, PolyPhen2,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26536348
DOI: 10.1371/journal.pone.0141906
PMCID: PMC4633051

Genes

ATM
INTS8
JAK3
KCNH8
NTRK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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