Article
Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas.
Blood - 13 Sept 2012
Vasmatzis George, Johnson Sarah H, Knudson Ryan A, Ketterling Rhett P, Braggio Esteban, Fonseca Rafael, Viswanatha David S, Law Mark E, Kip N Sertac, Ozsan Nazan, Grebe Stefan K, Frederick Lori A, Eckloff Bruce W, Thompson E Aubrey, Kadin Marshall E, Milosevic Dragana, Porcher Julie C, Asmann Yan W, Smith David I, Kovtun Irina V, Ansell Stephen M, Dogan Ahmet, Feldman Andrew L
Abstract excerpt
Peripheral T-cell lymphomas (PTCLs) are aggressive malignancies of mature T lymphocytes with 5-year overall survival rates of only ∼ 35%. Improvement in outcomes has been stymied by poor understanding of the genetics and molecular pathogenesis of PTCL, with a resulting paucity of molecular targets for therapy. We developed bioinformatic tools to identify chromosomal rearrangements using genome-wide,...
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