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Article

The Cellular Origin and Evolution of Breast Cancer.

Cold Spring Harbor perspectives in medicine - 1 Mar 2017

Zhang Mei, Lee Adrian V, Rosen Jeffrey M

Abstract excerpt

In this review, we will discuss how the cell of origin may modulate breast cancer intratumoral heterogeneity (ITH) as well as the role of ITH in the evolution of cancer. The clonal evolution and the cancer stem cell (CSC) models, as well as a model that integrates clonal evolution with a CSC hierarchy, have all been proposed to explain the development of ITH. The extent of ITH correlates with clinical outcome and...

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Share to Breast Neoplasms
Share to Disease Progression
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genetic Heterogeneity

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Share to Neoplastic Stem Cells

Source

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Identifiers

PMID: 28062556
DOI: 10.1101/cshperspect.a027128
PMCID: PMC5334246

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