Article
Opposing roles of PIK3CA gene alterations to EZH2 signaling in non-muscle invasive bladder cancer.
Oncotarget - 7 Feb 2017
Segovia Cristina, Martínez-Fernández Mónica, Dueñas Marta, Rubio Carolina, López-Calderón Fernando F, Costa Clotilde, Saiz-Ladera Cristina, Fernández-Grajera María, Duarte José, Muñoz Huberto García, de la Rosa Federico, Villacampa Felipe, Castellano Daniel, Paramio Jesús M
Abstract excerpt
The high rates of tumor recurrence and progression represent a major clinical problem in non-muscle invasive bladder cancer. Previous data showed that EZH2-dependent signaling mediates these processes, whereas the frequent alterations of PIK3CA gene (copy gains and mutations) are predictive of reduced recurrence. Here we show, using clinical samples and bladder cancer cell lines, a functional interaction between...
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