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Article

Exosomes as mediators of platinum resistance in ovarian cancer.

Oncotarget - 14 Feb 2017

Crow Jennifer, Atay Safinur, Banskota Samagya, Artale Brittany, Schmitt Sarah, Godwin Andrew K

Abstract excerpt

Exosomes have been implicated in the cell-cell transfer of oncogenic proteins and genetic material. We speculated this may be one mechanism by which an intrinsically platinum-resistant population of epithelial ovarian cancer (EOC) cells imparts its influence on surrounding tumor cells. To explore this possibility we utilized a platinum-sensitive cell line, A2780 and exosomes derived from its resistant subclones,...

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Topics

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Share to Antineoplastic Agents
Share to Carboplatin
Share to Carcinoma, Ovarian Epithelial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Exosomes

Share to Neoplasms, Glandular and Epithelial

Share to Ovarian Neoplasms

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Source

Open in PubMed Open full text

Identifiers

PMID: 28060758
DOI: 10.18632/oncotarget.14440
PMCID: PMC5355315

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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