Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

26 Dec 2016

Abstract excerpt

The identification of functional driver events in cancer is central to furthering our understanding of cancer biology and indispensable for the discovery of the next generation of novel drug targets. It is becoming apparent that more complex models of cancer are required to fully appreciate the contributing factors that drive tumorigenesis in vivo and increase the efficacy of novel therapies that make the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3D Printing in Biomedical Research
Share to Cancer Cells and Metastasis
Share to Cell Image Analysis Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28060271
DOI: 10.3791/54738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid CulturesPMID 28060271Read ↗

Patient-derived tumor spheroid cultures as a promising tool to assist personalized therapeutic decisions in breast cancerSemantic proximity Read ↗

Patient-derived Tumor Spheroid Cultures as a Promising Tool to Assist Personalized Therapeutic DecisionsSemantic proximity Read ↗

In Vitro Tissue Microarrays for Quick and Efficient Spheroid Characterization.Semantic proximity Read ↗

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines.Semantic proximity Read ↗

Breast tumour organoids: promising models for the genomic and functional characterisation of breast cancerSemantic proximity Read ↗

Identification and Validation of Driver Kinases from Next-Generation Sequencing Data.Semantic proximity Read ↗

Modeling patient-specific adenocarcinoma as spheroids enhances the authenticity of cancer hallmarks and therapeutic susceptibilitySemantic proximity Read ↗

3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer.Semantic proximity Read ↗

Breast Cancer MCF-7 Cell Spheroid Culture for Drug Discovery and DevelopmentSemantic proximity Read ↗

Preclinical model of organotypic culture for pharmacodynamic profiling of human tumorsSemantic proximity Read ↗

Kinome focused CRISPR-Cas9 screens in African ancestry patient-derived breast cancer organoids identifies essential kinases and synergy of EGFR and FGFR1 inhibitionSemantic proximity Read ↗

Evaluation of Tumor Response to Adjuvant Treatments using an Ex Vivo Culture of Breast Carcinoma Spheroids in a Microfluidic DeviceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.