Article

Modeling patient-specific adenocarcinoma as spheroids enhances the authenticity of cancer hallmarks and therapeutic susceptibility

2025-02-26

Abstract excerpt

Introduction: To help understand and develop treatments for cancer, it is important to have patient-specific, reliable and physiologically-relevant human culture models. Cells from solid tumors have traditionally been grown in 2-dimensional (2D) monolayers, however, it is known that cancer cells can self-organize into 3-dimensional (3D) entities (“spheroids”), mimicking the intercellular relationships they presuma...

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Literature Corpus work: db8b6dfc-86cd-5418-8e83-8af9f8366b5a
DOI: 10.1016/j.heliyon.2025.e42977

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