Article
Comprehensive Computational Analysis of GWAS Loci Identifies CCR2 as a Candidate Gene for Celiac Disease Pathogenesis.
Journal of cellular biochemistry - 1 Aug 2017
Banaganapalli Babajan, Rashidi Omran, Saadah Omar I, Wang Jun, Khan Imran Ali, Al-Aama Jumana Y, Shaik Noor Ahmad, Elango Ramu
Abstract excerpt
Celiac disease (CD) is a gluten intolerance disorder with known genetic contribution. The recent fine mapping and genome-wide association studies (GWAS) have identified up to 57 non-HLA CD susceptibility SNPs, majority of which are non-coding variants lacking any functional annotation. Therefore, we adopted multidimensional computational approach for uncovering the plausible mechanisms through which these GWAS...
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