Article
Zebrafish phenotypic screen identifies novel Notch antagonists.
Investigational new drugs - 1 Apr 2017
Velaithan Vithya, Okuda Kazuhide Shaun, Ng Mei Fong, Samat Norazwana, Leong Sze Wei, Faudzi Siti Munirah Mohd, Abas Faridah, Shaari Khozirah, Cheong Sok Ching, Tan Pei Jean, Patel Vyomesh
Abstract excerpt
Zebrafish represents a powerful in vivo model for phenotype-based drug discovery to identify clinically relevant small molecules. By utilizing this model, we evaluated natural product derived compounds that could potentially modulate Notch signaling that is important in both zebrafish embryogenesis and pathogenic in human cancers. A total of 234 compounds were screened using zebrafish embryos and 3 were...
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