Article
Small molecule screening in zebrafish: swimming in potential drug therapies.
Wiley interdisciplinary reviews. Developmental biology - 1 Jan 2000
Tamplin Owen J, White Richard M, Jing Lili, Kaufman Charles K, Lacadie Scott A, Li Pulin, Taylor Alison M, Zon Leonard I
Abstract excerpt
Phenotype-driven chemical genetic screens in zebrafish have become a proven approach for both dissection of developmental mechanisms and discovery of potential therapeutics. A library of small molecules can be arrayed into multiwell plates containing zebrafish embryos. The embryo becomes a whole organism in vivo bioassay that can produce a phenotype upon treatment. Screens have been performed that are based...
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