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Article

Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma.

Chinese medical journal - 20 Apr 2015

Du Yan, Zhang Yu-Wei, Pu Rui, Han Xue, Hu Jian-Ping, Zhang Hong-Wei, Wang Hong-Yang, Cao Guang-Wen

Abstract excerpt

BACKGROUND: Chronic hepatitis B virus (HBV) infection is the major cause of hepatocellular carcinoma (HCC). Some HBV mutants and dysregulation of phosphatase and tensin homolog (PTEN) may promote the development of HCC synergistically. We aimed to test the effects of PTEN genetic polymorphisms and their interactions with important HBV mutations on the development of HCC in HBV-infected subjects. METHODS:...

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Share to Carcinoma, Hepatocellular
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Liver Neoplasms

Share to Microfilament Proteins

Share to Phosphoric Monoester Hydrolases

Share to Polymorphism, Genetic

Share to PTEN Phosphohydrolase

Source

Open in PubMed Open full text

Identifiers

PMID: 25881591
DOI: 10.4103/0366-6999.155057
PMCID: PMC4832937

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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