Article
Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis.
Arthritis and rheumatism - 1 Aug 2007
Bang Holger, Egerer Karl, Gauliard Anke, Lüthke Kirsten, Rudolph Paul E, Fredenhagen Gert, Berg Wigbert, Feist Eugen, Burmester Gerd-R
Abstract excerpt
OBJECTIVE: Modification of antigens represents a trigger for the generation of autoantibodies. In the pathogenesis of rheumatoid arthritis (RA), citrullination of proteins has been shown to be a critical process, and the determination of antibodies against citrullinated antigens has been a diagnostic milestone. We undertook this study to determine whether antibodies to mutated and citrullinated vimentin (MCV)...
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