Article
Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis.
American journal of physiology. Renal physiology - 1 Mar 2017
Xavier Sandhya, Sahu Ranjit K, Landes Susan G, Yu Jing, Taylor Ronald P, Ayyadevara Srinivas, Megyesi Judit, Stallcup William B, Duffield Jeremy S, Reis Edimara S, Lambris John D, Portilla Didier
Abstract excerpt
We have examined the pathogenic role of increased complement expression and activation during kidney fibrosis. Here, we show that PDGFRβ-positive pericytes isolated from mice subjected to obstructive or folic acid injury secrete C1q. This was associated with increased production of proinflammatory cytokines, extracellular matrix components, collagens, and increased Wnt3a-mediated activation of Wnt/β-catenin...
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